Current programmes and projects

Open Calls
As a result of the first and second NACCAP open call, 4 partnership programmes were awarded:  

• Infectious diseases Network for Treatment and Research in Africa (INTERACT)
  INTERACT consists of the following 10 projects: 
  • Building sustainable clinical trial capacity 
  • Building and implementation of high quality data-systems 
  • Implementation research: operational aspects of diagnosis and treatment of HIVinfection and tuberculosis at the district level 
  • Assessing the impact of HAART on reproductive health of Rwandan women 
  • Incidence of and risk factors for selected adverse effects of HAART treatment in HIV-1 infected adults without a clinical suspicion of TB co-infection 
  • Immune Reconstitution Inflammatory Syndrome (IRIS) and other selected adverse effects of therapy in TB HIV co-infected patients first commencing HAART 
  • Surveillance of HIV-1 drug resistance in HAART treated patients and in the general population
  • Malaria treatment and Intermittent Preventive Treatment in pregnancy, with and without HIV infection 
  • The optimisation of chemotherapy for HIV/AIDS, tuberculosis and malaria in adults, pregnant women and children by studying the pharmacology of drugs  
  • HAART in Rwandan children 0-15 years: incidence, severity, risk factors and long term outcome of adverse effects

• College of Medicine, Malawi-Amsterdam-Liverpool partnership for Research Capacity Development through the establishment of a Research Support Centre in the College of Medicine, University of Malawi
  This Malawi-Amsterdam-Liverpool partnership programme consists of the following 4 projects:
  • Intermittent Preventive Therapy post-discharge (IPTpd); an innovative approach in the prevention of rebound severe malaria anaemia in young children 
  • RCT of iron supplementation in HIV infected children: Is iron safe and beneficial? 
  • Development of a Research Support Centre within the Post Graduate Institute of the College of Medicine (CoM), University of Malawi. 
  • The effect of iron supplementation on maternal morbidity in HIV-infected pregnant women (please note that this project is fully funded by Fogarty/NIH)

• APRIORI - African Poverty Related Infection Oriented Research Initiative
  The APRIORI programme consists of the following 5 projects:
  • Capacity building to establish KCRC
  • Phase I and II testing of malaria vaccines
  • Capacity building and establishment of clinical trial centre for testing new TB-vaccines (phase-I/IIa) and TB-drug interactions in the context of HIV in Africa
  • Concurrent treatment in TB and HIV co-infection
  • Development of drug regimens to shorten treatment for tuberculosis
  • APRIORI - African Poverty Related Infection Oriented Research Initiative 

• the ART-A Program - Developing an affordable HIV drug resistance test for Africa
  ART-A consists of the following 5 projects including 2 PhDs:
  • Development of a convenient sample collection device and extraction protocol to facilitate HIVDR testing in resource-limited settings
  • Development of affordable genotypic applications
  • Implementation and optimization of genotypic interpretation systems
  • Technology transfer and Training Work Package
  • Dissemination and communication
  • Prospective epidemiological studies of TB in neonates and adolescents in Karemo Division, Siaya district, Western Kenya, in preparation for future vaccine trials
  • TB-treatment brokering (still awaiting EDCTP contract)
  • Network of Excellence (still awaiting EDCTP contract)
  • Improving the balance between efficacy and development of resistance in women receiving single dose nevirapine (VIramune®, NVP) for the prevention of MTCT in Tanzania & Zambia
  • WHO-EDCTP training workshops for national regulatory authorities in Africa
  • Mapping research systems in Tanzania (COHRED)
  • Connecting the chain conference
  • Bursaries for the EDCTP Annual Forum 2009 in Arusha, Tanzania
  • Bursaries for the ESF conference 2009 in Brussels
  • Bursaries for the EDCTP Annual Forum 2007 in Burkina Faso
  • Bursaries for the EDCTP Annual Forum 2006 in Stockholm
 

Co-funding
As a result of the NACCAP co-funding call for EDCTP proposals the following programmes were awarded with a grant:

• Prospective epidemiological studies of TB in neonates and adolescents in Karemo Division, Siaya district, Western Kenya, in preparation for future vaccine trials
• TB-treatment (still awaiting EDCTP contracts)
• Network of Excellence (still awaiting EDCTP contracts)

Joint call
As a result of the NACCAP co-funding call for proposals of the joint call between the European Member States & EDCTP the following project was awarded with a grant:

• Improving the balance between efficacy and development of resistance in women receiving single dose nevirapine (VIramune®, NVP) for the prevention of MTCT in Tanzania & Zambia

Commissioned project(s)

• WHO-EDCTP training workshops for national regulatory authorities in Africa
• Mapping of research systems in Tanzania (COHRED)

Networking and communication activities
Since NACCAP thinks it is of utmost importance for African researchers to attend the Annual EDCTP Forum, NACCAP sponsored bursaries for African researchers affiliated with NACCAP financed research programmes for the following Forums:

• Bursaries for the EDCTP Annual Forum 2009 in Arusha, Tanzania
• Bursaries for the ESF conference 2009 in Brussels
• Bursaries for the EDCTP Annual Forum 2007 in Burkina Faso
• Bursaries for the EDCTP Annual Forum 2006 in Stockholm
• Bursaries for the ESSENCE group
• Bursaries for the exchange meeting NACCAP programmes